Endometrial Receptivity Array

A little sample of a woman’s endometrial lining is used for a genetic test called Endometrial Receptivity Analysis (ERA), which determines the ideal day to transfer the embryo during an IVF cycle. Conducting an endometrial receptivity analysis can be very helpful since it can identify the window of receptivity as one of the causes of infertility in women who have undergone two or more failed embryo transfers following in vitro fertilization (IVF).

How Does the Analysis of Endometrial Receptivity Operate?

Before your IVF or FET cycle, we will perform an endometrial biopsy in a mock embryo transfer cycle. The best day for embryo transfer and endometrial receptivity will then be determined by analyzing this sample. To determine the ideal period to try embryo implantation in a subsequent transfer cycle, the sample will be sent to a lab for molecular analysis. Three possible outcomes exist.

  • Pre-receptive: This means that a transfer now might not be the best option because the endometrium is not yet ready to accept the embryo.
  • Receptive: This means that the best time to transfer the embryo for implantation was at the exact moment the endometrial biopsy was performed.
  • Post-receptive: This means that the endometrium has progressed past the point at which embryo implantation was most successful.

 

The Best gynecologist will receive the test findings after they are finished and your endometrial receptivity has been established. Once your endometrium is ready for the developing embryo to implant, he or she can schedule your embryo transfer around that time, allowing you to customize your IVF treatment and make any required adjustments.

Is Endometrial Receptivity Analysis Something to Think About?

Your endometrial receptivity may not be a concern at this point in the process if you are newly trying to conceive, have never had IVF, and/or do not have a history of miscarriages. During your initial fertility appointment, the clinical team will examine your ovarian reserve and function as a woman. Additionally, they will usually do an ultrasound to view your uterus, ovaries, and uterine lining. It is not necessary to measure your endometrial receptivity unless the physician deems it necessary. 

In general, if you’ve had two or more unsuccessful IVF rounds with healthy embryos, the endometrial receptivity analysis is advised. Pre-implantation Genetic Testing for Aneuploidy (PGT, formerly known as PGS) can help enhance the chances of having a healthy baby and decrease the chances of miscarriage, therefore you might want to ask your doctor about it if you have had two or more losses.

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